The Ionic Dissociation Theory

Nucleosome dissociation at physiological ionic strengths.

Monomer nucleosomes purified on isokinetic sucrose gradients are shown to dissociate into component DNA and histones at physiological ionic strength upon dilution to a DNA concentration below 20 microgram/ml. The starting material is 11S, contains 145-190 BP DNA, and equimolar amounts of the four core histones with slightly less H1. Dilution of monomers in the presence of 0.14 M NaCl results in...

Ionic dissociation of NaCl on frozen water

Low-energy reactive ion scattering ~RIS! experiments show that NaCl dissociates almost completely on condensed ice surfaces prepared on Ru~001! even at 100 K forming solvated ions. NaCl by itself does not dissociate on a Ru~001! substrate; however, submonolayer coverages of water sets-in dissociation. Na ions thus created are immobile such that they do not migrate across one water bilayer ~BL! ...

Application of Chemometrics in determination of the effects of ionic and non-ionic surfactants on ac-id dissociation constant (pKa) of Meloxicam using spectrophotometric method

The purpose of this study was to determine the acid dissociation constants (pKa) of meloxicam in the presence of various surfactants including sodium lauryl sulfate (SLS) as an anionic surfactant, cetyltrimethylammonium bromide (CTAB) as a cationic surfactant and Triton® TX-100 (TX-100) as a non-ionic surfactant in different pre-determined concentrations. The related pKa was determined spec...

Toward the Mechanism of Ionic Dissociation in Water

We investigate the solvent effects leading to dissociation of sodium chloride in water. Thermodynamic analysis reveals dissociation to be driven energetically and opposed entropically, with the loss in entropy due to an increasing number of solvent molecules entering the highly coordinated ionic solvation shell. We show through committor analysis that the ion-ion distance is an insufficient rea...

Primary Documents the Theory of Dissociation